Module Details

The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title AN INTRODUCTION TO MEDICINAL CHEMISTRY
Code CHEM248
Coordinator Prof PM O'Neill
Chemistry
P.M.Oneill01@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2018-19 Level 5 FHEQ Second Semester 7.5

Pre-requisites before taking this module (or general academic requirements):

 

Aims

The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry, including an introduction to targets for drug action, methods of administration, qualitative and quantitative SAR, computer aided molecular design, solid phase chemistry /combinatorial chemistry.   The course also aims to describe in detail the chemical mechanisms of antitumour agents and will also include two lectures on carbohydrate chemistry.


Learning Outcomes

By the end of this module students are expected to have acquired an understanding of

  • The principle bonding interactions in drug receptor interactions
  • The basic concepts of structure activity relationships (SAR) and quantitative structure activity relationships (QSAR)
  • The principles behind computer aided molecular design and 3-D QSAR
  • Peptide synthesis, protecting groups and combinatorial chemistry
  • Chemical mechanisms of drugs that target DNA
  • Basic carbohydrate chemistry

and will be able to use these concepts and principles to solve simple problems in medicinal chemistry.


Teaching and Learning Strategies

Lecture -

Tutorial -

2x2hrs


Syllabus

1

Lecture 1 Introduction to Medicinal Chemistry: Overview of Targets for Drug Action
Lecture 2 Methods of Administration: The Pharmaceutical Phase
Lecture 3 Structures of Proteins: Bonds/ Energies Involved in Drug Receptor Interactions
Lecture 4 Structure Activity Relationships (SAR I)
Lecture 5 (SARII): Fluorine Substitution in Medicinal Chemistry
Lecture 6 Quantitative Structure Activity Relationships (QSAR)
Lecture 7 Computer Aided Molecular Design : 3D-QSAR
Lecture 8 Peptide Synthesis: Protecting Group Strategy in Synthesis
Lecture 9 Combinatorial Chemistry 1
Lecture 10 Combinatorial Chemistry II
Lecture 11 Drug Design – Solubility, Membrane Permeability
Lecture 12 Drug Design – Targeting Drugs
Lecture 13 DNA as a Target for Drugs
Lecture 14 Chemical Mechanisms of Anticancer Drugs
Lect ure 15 Carbohydrate Chemistry 1
Lecture 16 Carbohydrate Chemistry II


Recommended Texts

Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List:

Teaching Schedule

  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 16

  4

      20
Timetable (if known)     2x2hrs
 
       
Private Study 55
TOTAL HOURS 75

Assessment

EXAM Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
Written Exam  1.5 hours  second  90  August    Assessment 2 Notes (applying to all assessments) Assignments This work is not marked anonymously Written Examination  
CONTINUOUS Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
Coursework    second  10  No  Penalty for late submission applies - see Departmental handbook for details.  Assessment 1