Module Details
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title AN INTRODUCTION TO MEDICINAL CHEMISTRY
Code CHEM248
Coordinator Prof PM O'Neill
Chemistry
P.M.Oneill01@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2014-15 Level Two Second Semester 7.5

Aims

The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry, including an introduction to targets for drug action, methods of administration, qualitative and quantitative SAR, computer aided molecular design, solid phase chemistry /combinatorial chemistry.   The course also aims to describe in detail the chemical mechanisms of antitumour agents and will also include two lectures on carbohydrate chemistry.


Learning Outcomes

By the end of this module students are expected to have acquired an understanding of

  • The principle bonding interactions in drug receptor interactions
  • The basic concepts of structure activity relationships (SAR) and quantitative structure activity relationships (QSAR)
  • The principles behind computer aided molecular design and 3-D QSAR
  • Peptide synthesis, protecting groups and combinatorial chemistry
  • Chemical mechanisms of drugs that target DNA
  • Basic carbohydrate chemistry

and will be able to use these concepts and principles to solve simple problems in medicinal chemistry.


Syllabus
all 

Lecture 1 Introduction to Medicinal Chemistry: Overview of Targets for Drug Action
Lecture 2 Methods of Administration: The Pharmaceutical Phase
Lecture 3 Structures of Proteins: Bonds/ Energies Involved in Drug Receptor Interactions
Lecture 4 Structure Activity Relationships (SAR I)
Lecture 5 (SARII): Fluorine Substitution in Medicinal Chemistry
Lecture 6 Quantitative Structure Activity Relationships (QSAR)
Lecture 7 Computer Aided Molecular Design : 3D-QSAR
Lecture 8 Peptide Synthesis: Protecting Group Strategy in Synthesis
Lecture 9 Combinatorial Chemistry 1
Lecture 10 Combinatorial Chemistry II
Lecture 11 Drug Design – Solubility, Membrane Permeability
Lecture 12 Drug Design – Targeting Drugs
Lecture 13 DNA as a Target for Drugs
Lecture 14 Chemical Mechanisms of Anticancer Drugs
Lecture 15 Carbohydrate Chemistry 1
Lecture 16 C arbohydrate Chemistry II


Teaching and Learning Strategies

This course will be taught by a series of lectures in Chemistry. Students will learn how to apply their knowledge by completing a series of related tutorials.


Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 16

   4
2x2hrs
      20
Timetable (if known) Second Semester Tuesday 9:00- 10.00, Wednesday 10:00-11.00
  		  To be arranged
  		       
Private Study 55
TOTAL HOURS 75

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Written Examination  1.5 hours  second  90  August     
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Assignments    second  10  No  Penalty for late submission applies - see Departmental handbook for details.  This work is not marked anonymously  

Recommended Texts

An introduction to medicinal Chemistry, Graham. L . Patrick, ISBN:0-19-850533-7

Medicinal Chemistry: An introduction, Gareth Thomas, ISBN:0-471-48935-2