Module Details |
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module. |
Title | CATALYSIS | ||
Code | CHEM368 | ||
Coordinator |
Dr JA Iggo Chemistry |
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Year | CATS Level | Semester | CATS Value |
Session 2008-09 | M Level | Second Semester | 15 |
Aims |
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The aim of this module is to give students a broad, interdisciplinary, background in catalysis across the traditional divides within chemistry. |
Learning Outcomes |
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Syllabus |
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all |
The module is divided into three components, as follows: Inorganic Catalysis (Dr J A Iggo) The Inorganic Chemistry section of the module will introduce students to the application of organometallic complexes of transition metals in catalysis. Particular emphasis is placed on the mechanistic aspects of the subject. The approach is via worked examples chosen both for the commercial significance of the reaction and to illustrate how the catalytic mechanism can be studied. Organic and Bio-organic Catalysis (Dr R Bonar-Law) This section introduces the principles of chemical and biological catalysis: transition state and intermediate; the Hammond postulate, rate-determining step,simple kinetic analysis. Types of catalysis: General and specific acid/base catalysis, electrophilic and nucleophilic catalysis, intra molecular catalysisand effective molarity. Isotope effects as a probe of mechanism. These principles will provide the basis and understanding for a discussion of important enzyme-catalysed reactions in a series of case studies. The role of specific active site amino-acids and co-factors in catalytic mechanisms will be stressed; detailed knowledge of protein structure will not be required. Enzyme kinetics (Michaelis-Menten); types of enzyme inhibition. Hydrolytic enzymes: catalytic mechanism of a -chymotrypsin-the prototype; synthetic applications of hydrolases. Catalysis by metal ions. Redox enzymes: dehydrogenases (NAD/NADH) and cytochromes. Carbon-carbon bond forming enzymes, especially Class I aldolases; thiamine pyrophosphate (TPP). Functional group-transforming enzymes: pyridoxalphosphate (PLP)-case study. This section of the module provides a link between "conventional" chemistry and the chemistry of enzyme catalysis and shows students how the fundamental chemical mechanisms and principles are the same. A 50:50 split between chemical and biological catalysis will be aimed for. Heterogeneous Catalysis (Dr Y Khimyak) This set of 11 lectures aims to give an integrated description of the basic principles of heterogeneous catalysis,including the role and importance of adsorption phenomena in the determination of reaction kinetics, and uses well-known simple catalytic processes as examples to apply these notions. The importance of transport limitations (heat,mass) is also examined as well as molecular shape selective and confinement effects which are observed for zeolites and other microporous solid catalysts. A general view is thus provided of all the factors which determine the behaviour of heterogeneous, catalysts and their importance is illustrated through the discussion of case examples selected from important catalytic applications. |
Teaching and Learning Strategies |
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This module consists of 33 50-minute lectures. Lectures in the three sections will be given in parallel so as to allow students adequate time to absorb new concepts. Each section will be supported by one problem set and one workshop. The problem sets will be based on material covered in the lectures and detailed solutions of the problems will be discussed in the workshops. Students should expect to spend at least six hours per week in private study related to this module. This module is only offered in alternate years. Some students will take this module in Year 3 of their degree programme, while others will take it in Year 4 (consult year coordinator or programme documentation). |
Teaching Schedule |
Lectures | Seminars | Tutorials | Lab Practicals | Fieldwork Placement | Other | TOTAL | |
Study Hours |
30 |
6 |
36 | ||||
Timetable (if known) | |||||||
Private Study | 114 | ||||||
TOTAL HOURS | 150 |
Assessment |
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EXAM | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
Written Examination | 3 hr | second | 80 | Year 3/4 students resit at the next normal opportunity | Students to answer four questions from a choice of six. Questions will be a mix of "short answer" with some problem solving and essays. | |
CONTINUOUS | Duration | Timing (Semester) |
% of final mark |
Resit/resubmission opportunity |
Penalty for late submission |
Notes |
Problem Sets, each will contribute to 6.67% of the final marks for the module. | 3 sets | 2nd Semester | 20 | Year 3/4 students resit at the next normal opportunity. | Penalty for late submission applies - see Departmental handbook for details. | This work is not marked anonymously |
Recommended Texts |
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•“ An Introduction to Enzyme and Coenzyme Chemistry” T.Bugg. Blackwell Science, Oxford; Cambridge, Mass., USA, 1996.
•“Structure and Reactivity in Organic Chemistry” H. Maskill, Oxford University Press, 1991 (OUP primer)
•“Organometallics 1: complexes with transition metal carbon s-bonds” M.Bochmann and F. Bochner, Oxford University Press, 1994. (OUP primer)
•“Organometallics 2: complexes with transition metal carbon p bonds” M. Bochmann, Oxford University Press 1994. (OUP primer)
•“The basis and applications of heterogeneous catalysis” M. Bowker, Oxford Science Publications, 1998 (OUP primer)
•“Surfaces”, G. Attard and C. Barnes, Oxford Science Publications, 1999 (OUP primer)
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